Title *

The helper strategy in vector-transmission of plant virusesuse asterix (*) to get italics

Authors *

Di Mattia Jérémy, Zeddam Jean Louis, Uzest Marilyne and Stéphane BlancPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2023

Picture *

Abstract *

<p>An intriguing aspect of vector-transmission of plant viruses is the frequent involvement of a helper component (HC). HCs are virus-encoded non-structural proteins produced in infected plant cells that are mandatory for the transmission success. Over five decades, all data collected on HCs from unrelated viral species transmitted by distinct vector species were consistent with a unique mode of action designated “the bridge hypothesis”: the HC has two functional domains, one binding the virus particle and the other binding a putative receptor in the vector, creating a reversible molecular bridge between the two. This hypothesis appeared fully satisfactory as HCs were reported solely in viruses transmitted non-circulatively -- i.e. the virus particle binds externally to the mouthpart of its vector, and can later be released therefrom and inoculated. Recently, however, HCs have also been reported in viruses transmitted circulatively, where the virus particles are internalized in gut cells and cycle within the body to reach the salivary glands. In this more complex scheme of virus-vector interaction, a simple mode of action of HC compatible with the bridge hypothesis becomes questionable. In addition, while it had consistently been shown that the sequential acquisition of HC and virus particles could only work when HC was acquired first, a recent report shows that the reverse acquisition sequence can work in some case, again questioning the bridge hypothesis as a universal mode of action. Because of the importance of HC molecules in the vector-transmission of plant viruses, we here propose an exhaustive review of the field, of its historical perspective and most recent development.</p>

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Keywords (optional)

virus, transmission, plant, vector, helper component

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Evolution of hosts, infectious agents, or vectors, Interactions between hosts and infectious agents/vectors, Molecular biology of infections, Molecular genetics of hosts, infectious agents, or vectors, Plant diseases, Vectors, Viruses

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

Keith Perry, Cornell University, USA; klp3@cornell.edu, Xiao-Wei Wang, Zhejiang University: Hangzhou, Zhejiang, China; xwwang@zju.edu.cn, Stuart Gray, Cornell University, USA; smg3@cornell.edu, Murad Ghanim, Agricultural Research Organization, Volcani Institute, Israel; ghanim@volcani.agri.gov.il, Anna Whitfield, Plant virus vector interactions, Entomology and Plant pathology, North Carolina State University, USA; awhitfi@ncsu.edu, Claude Bragard, Université de Louvain, Belgium; claude.bragard@uclouvain.be, Juan-José Lopez-Moya, Center for Research in Agricultural Genomics, Barcelona, Spain; juanjose.lopez@cragenomica.es, Fernando-Garcia Arenal, Universidad Politecnica de Madrid, Spain; fernando.garciaarenal@upm.es, Alberto Fereres, CSIC, Madrid; a.fereres@csic.es, Taiyun Wei, Vector-born virus research center, Fujian Agriculture and Forestry University, China; weitaiyun@fafu.edu.cn

e.g. John Doe john@doe.com

No need for them to be recommenders of PCIInfections. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

Opposed reviewers - Suggest up to 5 people not to invite as reviewers. (Optional)

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Submission date

2022-10-28 17:32:39

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Christine Coustau

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